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NDB ID: 4PDQ    PDB ID: 4PDQ 


Title:

CRYSTAL STRUCTURE OF THE BACTERIAL RIBOSOMAL DECODING SITE IN COMPLEX WITH 4'-DEOXY-4'-FLUORO NEOMYCIN ANALOG

Molecular Description:

RNA (5'-*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C-3')

Deposited:

2014-04-21

Released:

2015-01-07

Structural Keywords:

A DOUBLE HELIX, FLIPPED OUT BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Hanessian, S., Saavedra, O.M., Vilchis-Reyes, M.A., Maianti, J.P., Kanazawa, H., Dozzo, P., Matias, R.D., Serio, A., Kondo, J.
Synthesis, broad spectrum antibacterial activity, and X-ray co-crystal structure of the decoding bacterial ribosomal A-site with 4'-deoxy-4'-fluoro neomycin analogs
Chem Sci, 5, pp. 4621 - 4632, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

H 3

Cell Constants:

a = 103.657   b = 103.657   c = 44.572 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.195 for 3522 reflections in the resolution range 19.6 to 3.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)