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NDB ID: 4TU9    PDB ID: 4TU9     NAKB(beta): 4TU9 


Title:

STRUCTURE OF U2AF65 VARIANT WITH BRU5G6 DNA

Molecular Description:

FRAGMENT OF BINDING DOMAINS 1 AND 2 OF THE SPLICING FACTOR U2AF 65 KDA/DNA Complex

Deposited:

2014-06-24

Released:

2014-11-26

Structural Keywords:

SMALL NA FRAGMENT

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Agrawal, A.A., McLaughlin, K.J., Jenkins, J.L., Kielkopf, C.L.
Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA. 
Proc.Natl.Acad.Sci.USA, 111, pp. 17420 - 17425, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 164.488   b = 37.183   c = 101.047 (Ångstroms)

α = 90.0   β = 125.57   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1922 for 33921 reflections in the resolution range 29.069 to 1.992 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)