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NDB ID: 4TUR    PDB ID: 4TUR     NAKB(beta): 4TUR 


Title:

HUMAN DNA POLYMERASE BETA INSERTING DCMPNPP OPPOSITE THE 5'G OF CISPLATIN CROSSLINKED GS (PT-GG2)

Molecular Description:

DNA polymerase beta/DNA Complex

Deposited:

2014-06-24

Released:

2014-10-01

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Koag, M.C., Lai, L., Lee, S.
Structural Basis for the Inefficient Nucleotide Incorporation Opposite Cisplatin-DNA Lesion by Human DNA Polymerase beta. 
J.Biol.Chem., 289, pp. 31341 - 31348, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 54.785   b = 79.335   c = 54.786 (Ångstroms)

α = 90.0   β = 107.81   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2046 for 22933 reflections in the resolution range 19.834 to 2.169 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)