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NDB ID: 4U27    PDB ID: 4U27 

Consolidated from the split entries: 4TPC, 4TPD, 4TPE, 4TPF

Title:

CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO FLOPRISTIN AND LINOPRISTIN.

Molecular Description:

30S ribosomal protein S2
30S ribosomal protein S3
30S ribosomal protein S4
30S ribosomal protein S5
30S ribosomal protein S6
30S ribosomal protein S7
30S ribosomal protein S8
30S ribosomal protein S9
30S ribosomal protein S10
30S ribosomal protein S11
30S ribosomal protein S12
30S ribosomal protein S13
30S ribosomal protein S14
30S ribosomal protein S15
30S ribosomal protein S16
30S ribosomal protein S17
30S ribosomal protein S18
30S ribosomal protein S19
30S ribosomal protein S20
30S ribosomal protein S21/RNA Complex

Deposited:

2014-07-16

Released:

2014-07-30

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 51 protein sequences

Primary Citation:

Noeske, J., Huang, J., Olivier, N.B., Giacobbe, R.A., Zambrowski, M., Cate, J.H.
Synergy of streptogramin antibiotics occurs independently of their effects on translation. 
Antimicrob.Agents Chemother., 58, pp. 5269 - 5279, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 211.97   b = 434.65   c = 623.91 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2155 for 1244949 reflections in the resolution range 69.364 to 2.8 Ångstroms with Fobs >  1.99 sigma(Fobs) and with I >  0.0 sigma(I)