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NDB ID: 4V9R    PDB ID: 4V9R 

Consolidated from the split entries: 4NVU, 4NVV, 4NVW, 4NVX

Title:

CRYSTAL STRUCTURE OF ANTIBIOTIC DITYROMYCIN BOUND TO 70S RIBOSOME

Molecular Description:

PROTEIN/RNA Complex

Deposited:

2013-12-05

Released:

2014-07-09

Nucleic Acid Sequence:

Click to show/hide 5 nucleic acid sequences

Protein Sequence:

Click to show/hide 50 protein sequences

Primary Citation:

Bulkley, D., Brandi, L., Polikanov, Y.S., Fabbretti, A., O'Connor, M., Gualerzi, C.O., Steitz, T.A.
The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation. 
Cell Rep, 6, pp. 357 - 365, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 210.08   b = 449.83   c = 619.65 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2061 for 1142889 reflections in the resolution range 49.739 to 3.0 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)