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NDB ID: 4W5N    PDB ID: 4W5N 


Title:

THE CRYSTAL STRUCTURE OF HUMAN ARGONAUTE2 BOUND TO A DEFINED GUIDE RNA

Molecular Description:

Human Argonaute2/RNA Complex

Deposited:

2014-08-18

Released:

2014-11-12

Structural Keywords:

SMALL NA FRAGMENT

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Schirle, N.T., Sheu-Gruttadauria, J., MacRae, I.J.
Gene regulation. Structural basis for microRNA targeting. 
Science, 346, pp. 608 - 613, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 63.117   b = 108.87   c = 68.071 (Ångstroms)

α = 90.0   β = 106.93   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2192 for 19358 reflections in the resolution range 38.98 to 2.9 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)