NDB ID: 4WFB PDB ID: 4WFB 
Title:
THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH BC-3205
Molecular Description:
RNA (2923-MER)
RNA (114-MER)
Deposited:
2014-09-14
Released:
2015-10-21
Nucleic Acid Sequence:
Click to show/hide 2 nucleic acid sequences
Chain X
GAUUAAGUUAUUAAGGGCGCACGGUGGAUGCCUUGGCACUAGAAGCCAAUGAAGGACGUUACUAACGACGAUAUGCUUUG GGGAGCUGU
AAGUAAGCUUUGAUCCAGAGAUUUCCGAAUGGGGAAACCCAGCAUGAGUUAUGUCAUGUUAUCGAUAUGUG AAUACAUAGCAUAUCAGA
AGGCACACCCGGAGAACUGAAACAUCUUAGUACCCGGAGGAAGAGAAAGAAAAUUCGAUUCC CUUAGUAGCGGCGAGCGAAACGGGAAG
AGCCCAAACCAACAAGCUUGCUUGUUGGGGUUGUAGGACACUCUAUACGGAGU UACAAAGGACGACAUUAGACGAAUCAUCUGGAAAGA
UGAAUCAAAGAAGGUAAUAAUCCUGUAGUCGAAAAUGUUGUCUC UCUUGAGUGGAUCCUGAGUACGACGGAGCACGUGAAAUUCCGUCG
GAAUCUGGGAGGACCAUCUCCUAAGGCUAAAUACU CUCUAGUGACCGAUAGUGAACCAGUACCGUGAGGGAAAGGUGAAAAGCACCCCG
GAAGGGGAGUGAAAUAGAACCUGAAA CCGUGUGCUUACAAGUAGUCAGAGCCCGUUAAUGGGUGAUGGCGUGCCUUUUGUAGAAUGAAC
CGGCGAGUUACGAUUUG AUGCAAGGUUAAGCAGUAAAUGUGGAGCCGUAGCGAAAGCGAGUCUGAAUAGGGCGUUUAGUAUUUGGUCGU
AGACCCGA AACCAGGUGAUCUACCCUUGGUCAGGUUGAAGUUCAGGUAACACUGAAUGGAGGACCGAACCGACUUACGUUGAAAAGUG
AGCGGAUGAACUGAGGGUAGCGGAGAAAUUCCAAUCGAACCUGGAGAUAGCUGGUUCUCUCCGAAAUAGCUUUAGGGCUA GCCUCAAGU
GAUGAUUAUUGGAGGUAGAGCACUGUUUGGACGAGGGGCCCCUCUCGGGUUACCGAAUUCAGACAAACUCC GAAUGCCAAUUAAUUUAA
CUUGGGAGUCAGAACAUGGGUGAUAAGGUCCGUGUUCGAAAGGGAAACAGCCCAGACCACCA GCUAAGGUCCCAAAAUAUAUGUUAAGU
GGAAAAGGAUGUGGCGUUGCCCAGACAACUAGGAUGUUGGCUUAGAAGCAGCC AUCAUUUAAAGAGUGCGUAAUAGCUCACUAGUCGAG
UGACACUGCGCCGAAAAUGUACCGGGGCUAAACAUAUUACCGAA GCUGUGGAUUGUCCUUUGGACAAUGGUAGGAGAGCGUUCUAAGGG
CGUUGAAGCAUGAUCGUAAGGACAUGUGGAGCGCU UAGAAGUGAGAAUGCCGGUGUGAGUAGCGAAAGACGGGUGAGAAUCCCGUCCAC
CGAUUGACUAAGGUUUCCAGAGGAAG GCUCGUCCGCUCUGGGUUAGUCGGGUCCUAAGCUGAGGCCGACAGGCGUAGGCGAUGGAUAAC
AGGUUGAUAUUCCUGUA CCACCUAUAAUCGUUUUAAUCGAUGGGGGGACGCAGUAGGAUAGGCGAAGCGUGCGAUUGGAUUGCACGUCU
AAGCAGUA AGGCUGAGUAUUAGGCAAAUCCGGUACUCGUUAAGGCUGAGCUGUGAUGGGGAGAAGACAUUGAGUCUUCGAGUCGUUGA
UUUCACACUGCCGAGAAAAGCCUCUAGAUAGAAAAUAGGUGCCCGUACCGCAAACCGACACAGGUAGUCAAGAUGAGAAU UCUAAGGUG
AGCGAGCGAACUCUCGUUAAGGAACUCGGCAAAAUGACCCCGUAACUUCGGGAGAAGGGGUGCUCUUUAGG GUUAACGCCCAGAAGAGC
CGCAGUGAAUAGGCCCAAGCGACUGUUUAUCAAAAACACAGGUCUCUGCUAAACCGUAAGGU GAUGUAUAGGGGCUGACGCCUGCCCGG
UGCUGGAAGGUUAAGAGGAGUGGUUAGCUUCUGCGAAGCUACGAAUCGAAGCC CCAGUAAACGGCGGCCGUAACUAUAACGGUCCUAAG
GUAGCGAAAUUCCUUGUCGGGUAAGUUCCGACCCGCACGAAAGG CGUAACGAUUUGGGCACUGUCUCAACGAGAGACUCGGUGAAAUCA
UAGUACCUGUGAAGAUGCAGGUUACCCGCGACAGG ACGGAAAGACCCCGUGGAGCUUUACUGUAGCCUGAUAUUGAAAUUCGGCACAGC
UUGUACAGGAUAGGUAGGAGCCUUUG AAACGUGAGCGCUAGCUUACGUGGAGGCGCUGGUGGGAUACUACCCUAGCUGUGUUGGCUUUC
UAACCCGCACCACUUAU CGUGGUGGGAGACAGUGUCAAGCGGGCAGUUUGACUGGGGCGGUCGCCUCCUAAAAGGUAACGGAGGCGCUC
AAAGGUUC CCUCAGAAUGGUUGGAAAUCAUUCAUAGAGUGUAAAGGCAUAAGGGAGCUUGACUGCGAGACCUACAAGUCGAGCAGGGU
CGAAAGACGGACUUAGUGAUCCGGUGGUUCCGCAUGGAAGGGCCAUCGCUCAACGGAUAAAAGCUACCCCGGGGAUAACA GGCUUAUCU
CCCCCAAGAGUUCACAUCGACGGGGAGGUUUGGCACCUCGAUGUCGGCUCAUCGCAUCCUGGGGCUGUAGU CGGUCCCAAGGGUUGGGC
UGUUCGCCCAUUAAAGCGGUACGCGAGCUGGGUUCAGAACGUCGUGAGACAGUUCGGUCCCU AUCCGUCGUGGGCGUAGGAAAUUUGAG
AGGAGCUGUCCUUAGUACGAGAGGACCGGGAUGGACAUACCUCUGGUGUACCA GUUGUCGUGCCAACGGCAUAGCUGGGUAGCUAUGUG
UGGACGGGAUAAGUGCUGAAAGCAUCUAAGCAUGAAGCCCCCCU CAAGAUGAGAUUUCCCAACUUCGGUUAUAAGAUCCCUCAAAGAUG
AUGAGGUUAAUAGGUUCGAGGUGGAAGCAUGGUGA CAUGUGGAGCUGACGAAUACUAAUCGAUCGAAGACUUAAUCAA
Chain Y
UCUGGUGACUAUAGCAAGGAGGUCACACCUGUUCCCAUGCCGAACACAGAAGUUAAGGUCUUUAGCGACGAUGGUAGCCA ACUUACGUU
CCGCUAGAGUAGAACGUUGCCAGGC
Protein Sequence:
Click to show/hide 26 protein sequences
Chain W
MAKLQITLTRSVIGRPETQRKTVEALGLKKTNSSVVVEDNPAIRGQINKVKHLVTVEEK
Chain Z
MAVPKRRTSKTRKNKRRTHFKISVPGMTECPNCGREYKLSHRVCKNCGSYNGEEVAAK
Chain 2
MVKRTYQPNKRKHSKVHGFRKRMSTKNGRKVLARRRRKGRKVLSA
Chain 3
MPKMKTHRGAAKRVKRTASGQLKRSRAFTSHLFANKSTKQKRQLRKARLVSKSDMKRVKQLLAYKK
Chain S
MASLKSIIRQGKQTRSDLKQLRKSGKVPAVVYGYGTKNVSVKVDEVEFIKVIREVGRNGVIELGVGSKTIKVMVADYQFD PLKNQITHI
DFLAINMSEERTVEVPVQLVGEAVGAKEGGVVEQPLFNLEVTATPDNIPEAIEVDITELNINDSLTVADVK VTGDFKIENDSAESVVTV
VAPTEEPTEEEIEAMEGEQQTEEPEVVGESKEDEEKTEE
Chain T
MLKLNLQFFASKKGVSSTKNGRDSESKRLGAKRADGQFVTGGSILYRQRGTKIYPGENVGRGGDDTLFAKIDGVVKFERK GRDKKQVSV
YAVAE
Chain U
MGKQCFVTGRKASTGNRRSHALNSTKRRWNANLQKVRILVDGKPKKVWVSARALKSGKVTRV
Chain V
MKAKEIRDLTTSEIEEQIKSSKEELFNLRFQLATGQLEETARIRTVRKTIARLKTVAREREIEQSKANQ
Chain 4
MKVRPSVKPICEKCKVIKRKGKVMVICENPKHKQRQG
Chain A
MAIKKYKPITNGRRNMTSLDFAEITKTTPEKSLLKPLPKKAGRNNQGKLTVRHHGGGHKRQYRVIDFKRNKDGINAKVDS IQYDPNRSA
NIALVVYADGEKRYIIAPKGLEVGQIVESGAEADIKVGNALPLQNIPVGTVVHNIELKPGKGGQIARSAGA SAQVLGKEGKYVLIRLRS
GEVRMILSTCRATIGQVGNLQHELVNVGKAGRSRWKGIRPTVRGSVMNPNDHPHGGGEGRAP IGRPSPMSPWGKPTLGKKTRRGKKSSD
KLIVRGRKKK
Chain C
MANYDVLKLDGTKSGSIELSDAVFGIEPNNSVLFEAINLQRASLRQGTHAVKNRSAVSGGGRKPWKQKGTGRARQGTIRA PQWRGGGIV
FGPTPRSYAYKMPKKMRRLALRSALSFKAQENGLTVVDAFNFEAPKTKEFKNVLSTLEQPKKVLVVTENED VNVELSARNIPGVQVTTA
QGLNVLDITNADSLVITEAAAKKVEEVLG
Chain B
MTKGILGRKIGMTQVFGENGELIPVTVVEAKENVVLQKKTVEVDGYNAIQVGFEDKKAYKKDAKSNKYANKPAEGHAKKA DAAPKRFIR
EFRNVDVDAYEVGQEVSVDTFVAGDVIDVTGVSKGKGFQGAIKRHGQSRGPMSHGSHFHRAPGSVGMASDA SRVFKGQKMPGRMGGNTV
TVQNLEVVQVDTENKVILVKGNVPGPKKGLVEIRTSIKKGNK
Chain E
MSRVGKKIIDIPSDVTVTFDGNHVTVKGPKGELSRTLNERMTFKQEENTIEVVRPSDSKEDRTNHGTTRALLNNMVQGVS QGYVKVLEL
VGVGYRAQMQGKDLILNVGYSHPVEIKAEENITFSVEKNTVVKVEGISKEQVGALASNIRSVRPPEPYKGK GIRYQGEYVRRKEGKTGK
Chain D
MNRLKEKFNTEVTENLMKKFNYSSVMEVPKIDKIVVNMGVGDAVQNSKVLDNAVEELELITGQKPLVTKAKKSIATFRLR EGMPIGAKV
TLRGERMYEFLDKLISVSLPRVRDFQGVSKKAFDGRGNYTLGVKEQLIFPEIDYDKVSKVRGMDIVIVTTA NTDEEARELLANFGMPFR
K
Chain H
MIQQETRLKVADNSGAREVLTIKVLGGSGRKTANIGDVIVCTVKNATPGGVVKKGDVVKAVIVRTKSGVRRNDGSYIKFD ENACVIIRD
DKGPRGTRIFGPVARELREGNFMKIVSLAPEVL
Chain G
MRQTFMANESNIERKWYVIDAEGQTLGRLSSEVASILRGKNKVTYTPHVDTGDYVIVINASKIEFTGNKETDKVYYRHSN HPGGIKSIT
AGELRRTNPERLIENSIKGMLPSTRLGEKQGKKLFVYGGAEHPHAAQQPENYELRG
Chain J
MLLPKRVKYRRQHRPKTTGRSKGGNYVTFGEFGLQATTTSWITSRQIESARIAMTRYMKRGGKVWIKIFPHTPYTKKPLE VRMGAGKGA
VEGWIAVVKPGRILFEVAGVSEEVAREALRLASHKLPVKTKFVKREELGGETNES
Chain I
MKLHELKPAEGSRKERNRVGRGVATGNGKTSGRGHKGQKARSGGGVRPGFEGGQLPLFRRLPKRGFTNINRKEYAIVNLD QLNKFEDGT
EVTPALLVESGVVKNEKSGIKILGNGSLDKKLTVKAHKFSASAAEAIDAKGGAHEVI
Chain L
MISKIDKNKVRLKRHARVRTNLSGTAEKPRLNVYRSNKHIYAQIIDDNKGVTLAQASSKDSDIATTATKVELATKVGEAI AKKAADKGI
KEIVFDRGGYLYHGRVKALAEAARESGLEF
Chain K
MGYRKLGRTSDQRKAMLRDLATSLIISERIETTEARAKEVRSVVEKLITLGKKGDLASRRNAAKTLRNVEILNEDETTQT ALQKLFGEI
AERYTERQGGYTRILKQGPRRGDGAESVIIELV
Chain N
MPRVKGGTVTRARRKKTIKLAKGYFGSKHTLYKVAKQQVMKSGQYAFRDRRQRKRDFRKLWITRINAAARQHEMSYSRLM NGLKKAGID
INRKMLSEIAISDEKAFAQLVTKAKDALK
Chain M
MTNHKLIEAVTKSQLRTDLPSFRPGDTLRVHVRIIEGTRERIQVFEGVVIKRRGGGVSETFTVRKISSGVGVERTFPLHT PKIEKIEVK
RRGKVRRAKLYYLRSLRGKAARIQEIR
Chain P
MEAKAVARTIRIAPRKVRLVLDLIRGKNAAEAIAILKLTNKASSPVIEKVLMSALANAEHNYDMNTDELVVKEAYANEGP TLKRFRPRA
QGRASAINKRTSHITIVVSDGKEEAKEA
Chain O
MFAIIETGGKQIKVEEGQEIFVEKLDVNEGDTFTFDKVLFVGGDSVKVGAPTVEGATVTATVNKQGRGKKITVFTYKRRK NSKRKKGHR
QPYTKLTIDKINA
Chain R
MHIKKGDNVKVIAGKDKGKEGKVIATLPKKDRVVVEGVNIMKKHQKPTQLNPEGGILETEAAIHVSNVQLLDPKTNEPTR VGYKFVDGK
KVRIAKKSGEEIKSNN
Chain Q
MEARDILKRPVITEKSSEAMAEDKYTFDVDTRVNKTQVKMAVEEIFNVKVASVNIMNYKPKKKRMGRYQGYTNKRRKAIV TLKEGSIDL
FN
Primary Citation:
Eyal, Z., Matzov, D., Krupkin, M., Wekselman, I., Paukner, S., Zimmerman, E., Rozenberg, H., Bashan, A., Yonath, A.
Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus. 
Proc.Natl.Acad.Sci.USA, 112, pp. E5805 - E5814, 2015.
Experimental Information:
X-RAY DIFFRACTION
Space Group:
P 65 2 2
Cell Constants:
a = 280.918 b = 280.918 c = 875.585 (Ångstroms)
α = 90.0 β = 90.0 γ = 120.0 (degrees)
Refinement:
The structure was refined using the PHENIX program.
The R value is 0.2061 for 253650 reflections in
the resolution range 49.539 to 3.43 Ångstroms
with Fobs > 1.35 sigma(Fobs) and with I > 0.0 sigma(I)