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NDB ID: 4WOI    PDB ID: 4WOI 


Title:

4,5-LINKED AMINOGLYCOSIDE ANTIBIOTICS REGULATE THE BACTERIAL RIBOSOME BY TARGETING DYNAMIC CONFORMATIONAL PROCESSES WITHIN INTERSUBUNIT BRIDGE B2

Molecular Description:

30S ribosomal protein S2
30S ribosomal protein S3
30S ribosomal protein S4
30S ribosomal protein S5
30S ribosomal protein S6
30S ribosomal protein S7
30S ribosomal protein S8
30S ribosomal protein S9
30S ribosomal protein S10
30S ribosomal protein S11
30S ribosomal protein S12
30S ribosomal protein S13
30S ribosomal protein S14
30S ribosomal protein S15
30S ribosomal protein S16
30S ribosomal protein S17
30S ribosomal protein S18
30S ribosomal protein S19
30S ribosomal protein S20
30S ribosomal protein S21
ribosome recycling factor RRF/RNA Complex

Deposited:

2014-10-15

Released:

2015-08-05

Nucleic Acid Sequence:

Click to show/hide 5 nucleic acid sequences

Protein Sequence:

Click to show/hide 51 protein sequences

Primary Citation:

Wasserman, M.R., Pulk, A., Zhou, Z., Altman, R.B., Zinder, J.C., Green, K.D., Garneau-Tsodikova, S., Doudna Cate, J.H., Blanchard, S.C.
Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions. 
Nat Commun, 6, pp. 7896 - 7896, 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 212.1   b = 435.24   c = 614.44 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.0 for 909645 reflections in the resolution range 70.0 to 3.0 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)