A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 12-Jan-2022 number of released structures: 11872
Search for released structures

NDB ID: 4WTF    PDB ID: 4WTF 


Title:

CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH GS-639475, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-CAAAAUUU

Molecular Description:

HCV NS5B GENOTYPE 2A JFH-1 ISOLATE S15G C223H V321I DELTA8/RNA Complex

Deposited:

2014-10-30

Released:

2015-02-11

Structural Keywords:

A DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Appleby, T.C., Perry, J.K., Murakami, E., Barauskas, O., Feng, J., Cho, A., Fox, D., Wetmore, D.R., McGrath, M.E., Ray, A.S., Sofia, M.J., Swaminathan, S., Edwards, T.E.
Structural basis for RNA replication by the hepatitis C virus polymerase. 
Science, 347, pp. 771 - 775, 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65

Cell Constants:

a = 141.65   b = 141.65   c = 91.64 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.189 for 30517 reflections in the resolution range 50.0 to 2.65 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)