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NDB ID: 4X6A    PDB ID: 4X6A 


Title:

CRYSTAL STRUCTURE OF YEAST RNA POLYMERASE II ENCOUNTERING OXIDATIVE CYCLOPURINE DNA LESIONS

Molecular Description:

DNA-directed RNA polymerase II subunit RPB1
DNA-directed RNA polymerase II subunit RPB2
DNA-directed RNA polymerase II subunit RPB3
DNA-directed RNA polymerases I
II
and III subunit RPABC1
iaDNA-directed RNA polymerases I
II
and III subunit RPABC2
DNA-directed RNA polymerases I
II
and III subunit RPABC3
DNA-directed RNA polymerase II subunit RPB9
DNA-directed RNA polymerases I
II
and III subunit RPABC5
DNA-directed RNA polymerase II subunit RPB11
DNA-directed RNA polymerases I
II
and III subunit RPABC4/RNA Complex

Deposited:

2014-12-07

Released:

2015-02-04

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 10 protein sequences

Primary Citation:

Walmacq, C., Wang, L., Chong, J., Scibelli, K., Lubkowska, L., Gnatt, A., Brooks, P.J., Wang, D., Kashlev, M.
Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. 
Proc.Natl.Acad.Sci.USA, 112, pp. E410 - E419, 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 156.55   b = 220.334   c = 191.563 (Ångstroms)

α = 90.0   β = 97.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.2513 for 47410 reflections in the resolution range 50.0 to 3.96 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)