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NDB ID: 4YQW    PDB ID: 4YQW 


Title:

MUTANT HUMAN DNA POLYMERASE ETA Q38A/R61A INSERTING DCTP OPPOSITE TEMPLATE G

Molecular Description:

Mutant Human DNA Polymerase Eta Q38A/R61A/DNA Complex

Deposited:

2015-03-13

Released:

2015-05-13

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine. 
J.Biol.Chem., 290, pp. 15921 - 15933, 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 61

Cell Constants:

a = 99.238   b = 99.238   c = 82.378 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.177 for 28355 reflections in the resolution range 42.971 to 2.064 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)