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NDB ID: 4Z2E    PDB ID: 4Z2E 


Title:

QUINOLONE(TROVAFLOXACIN)-DNA CLEAVAGE COMPLEX OF GYRASE FROM S. PNEUMONIAE

Molecular Description:

GyrA59 subunit of gyrase from Streptococcus pneumoniae
GyrB30 subunit of gyrase from Streptococcus pneumoniae/DNA Complex

Deposited:

2015-03-29

Released:

2016-09-14

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Laponogov, I., Veselkov, D.A., Pan, X.-S., Selvarajah, J., Crevel, I.M.-T., Fisher, L.M., Sanderson, M.R.
Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
To Be Published, , pp. - , 0.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 94.19   b = 96.62   c = 275.21 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2496 for 33472 reflections in the resolution range 56.045 to 3.46 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)