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NDB ID: 4Z47    PDB ID: 4Z47 


Title:

STRUCTURE OF THE ENZYME-PRODUCT COMPLEX RESULTING FROM TDG ACTION ON A GU MISMATCH IN THE PRESENCE OF EXCESS BASE

Molecular Description:

G/T mismatch-specific thymine DNA glycosylase/DNA Complex

Deposited:

2015-04-01

Released:

2015-09-16

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Malik, S.S., Coey, C.T., Varney, K.M., Pozharski, E., Drohat, A.C.
Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. 
Nucleic Acids Res., 43, pp. 9541 - 9552, 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 89.305   b = 53.322   c = 82.297 (Ångstroms)

α = 90.0   β = 95.31   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.1428 for 61716 reflections in the resolution range 45.73 to 1.45 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)