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NDB ID: 4ZTU    PDB ID: 4ZTU 


Title:

STRUCTURAL BASIS FOR PROCESSIVITY AND ANTIVIRAL DRUG TOXICITY IN HUMAN MITOCHONDRIAL DNA REPLICASE

Molecular Description:

DNA polymerase subunit gamma-1
DNA polymerase subunit gamma-2
mitochondrial/DNA Complex

Deposited:

2015-05-15

Released:

2015-09-23

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Szymanski, M.R., Kuznestov, V.B., Shumate, C.K., Meng, Q., Lee, Y.-S., Patel, G., Patel, S.S., Yin, Y.W.
Structural basis for processivity and antiviral drug toxicity in human mitochondrial DNA replicase 
EMBO J., 34, pp. 1959 - , 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 21 2

Cell Constants:

a = 217.575   b = 217.575   c = 168.277 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.0 for 60405 reflections in the resolution range 42.67 to 3.299 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)