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NDB ID: NA1436    PDB ID: 4A0K 


Title:

STRUCTURE OF DDB1-DDB2-CUL4A-RBX1 BOUND TO A 12 BP ABASIC SITE CONTAINING DNA-DUPLEX

Molecular Description:

CULLIN-4A
E3 UBIQUITIN-PROTEIN LIGASE RBX1 (E.C.6.3.2.-)
DNA DAMAGE-BINDING PROTEIN 1
DNA DAMAGE-BINDING PROTEIN 2

Deposited:

2011-09-09

Released:

2011-12-14

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Fischer, E.S., Scrima, A., Bohm, K., Matsumoto, S., Lingaraju, G.M., Faty, M., Yasuda, T., Cavadini, S., Wakasugi, M., Hanaoka, F., Iwai, S., Gut, H., Sugasawa, K., Thoma, N.H.
The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation. 
Cell(Cambridge,Mass.), 147, pp. 1024 - , 2011.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 210.65   b = 78.02   c = 276.62 (Ångstroms)

α = 90.0   β = 108.5   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2691 for 11036 reflections in the resolution range 19.977 to 5.93 Ångstroms with Fobs >  2.05 sigma(Fobs) and with I >  0.0 sigma(I)