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NDB ID: NA2337    PDB ID: 4B9M 


Title:

STRUCTURE OF THE HIGH FIDELITY DNA POLYMERASE I WITH AN OXIDATIVE FORMAMIDOPYRIMIDINE-DA DNA LESION -THYMINE BASEPAIR IN THE POST- INSERTION SITE.

Molecular Description:

DNA POLYMERASE I (E.C.2.7.7.7)

Deposited:

2012-09-05

Released:

2013-04-17

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Gehrke, T.H., Lischke, U., Gasteiger, K.L., Schneider, S., Arnold, S., Muller, H.C., Stephenson, D.S., Zipse, H., Carell, T.
Unexpected Non-Hoogsteen-Based Mutagenicity Mechanism of Fapy-DNA Lesions. 
Nat.Chem.Biol., 9, pp. 455 - , 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 88.419   b = 93.656   c = 105.053 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.1875 for 52362 reflections in the resolution range 50.0 to 2.05 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)