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NDB ID: NA2224    PDB ID: 4IRI 


Title:

AUTO-INHIBITED ERG ETS DOMAIN-DNA COMPLEX

Molecular Description:

Transcriptional regulator ERG

Deposited:

2013-01-14

Released:

2013-07-31

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Regan, M.C., Horanyi, P.S., Pryor, E.E., Sarver, J.L., Cafiso, D.S., Bushweller, J.H.
Structural and dynamic studies of the transcription factor ERG reveal DNA binding is allosterically autoinhibited. 
Proc.Natl.Acad.Sci.USA, 110, pp. 13374 - 13379, 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 2 2

Cell Constants:

a = 51.486   b = 51.486   c = 141.313 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.19144 for 5250 reflections in the resolution range 34.76 to 2.77 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)