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NDB ID: NA2645    PDB ID: 4M2Y 


Title:

STRUCTURE OF HUMAN DNA POLYMERASE BETA COMPLEXED WITH 8-BRG AS THE TEMPLATE BASE IN A 1-NUCLEOTIDE GAPPED DNA

Molecular Description:

DNA polymerase beta (E.C.2.7.7.7
4.2.99.-)

Deposited:

2013-08-05

Released:

2014-01-22

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Koag, M.C., Min, K., Lee, S.
Structural basis for promutagenicity of 8-halogenated Guanine. 
J.Biol.Chem., 289, pp. 6289 - 6298, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 54.554   b = 79.271   c = 54.915 (Ångstroms)

α = 90.0   β = 105.48   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.2151 for 19695 reflections in the resolution range 19.83 to 2.27 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)