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NDB ID: NA2656    PDB ID: 4M9N 


Title:

DNA POLYMERASE BETA E295K SOAKED WITH DATP

Molecular Description:

DNA polymerase beta (E.C.2.7.7.7
4.2.99.-)

Deposited:

2013-08-14

Released:

2013-10-16

Structural Keywords:

B DOUBLE HELIX, NICKED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Eckenroth, B.E., Towle-Weicksel, J.B., Sweasy, J.B., Doublie, S.
The E295K Cancer Variant of Human Polymerase beta Favors the Mismatch Conformational Pathway during Nucleotide Selection. 
J.Biol.Chem., 288, pp. 34850 - 34860, 2013.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 54.523   b = 79.215   c = 54.685 (Ångstroms)

α = 90.0   β = 106.24   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1951 for 36691 reflections in the resolution range 13.923 to 2.275 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)