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NDB ID: NA2817    PDB ID: 4O3S 


Title:

CRYSTAL STRUCTURE OF HUMAN POLYMERASE ETA EXTENDING AN 8-OXOG DNA LESION: POST INSERTION OF 8-OXOG-DC PAIR

Molecular Description:

DNA polymerase eta (E.C.2.7.7.7)

Deposited:

2013-12-18

Released:

2014-04-30

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Patra, A., Nagy, L.D., Zhang, Q., Su, Y., Muller, L., Guengerich, F.P., Egli, M.
Kinetics, Structure, and Mechanism of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Bypass by Human DNA Polymerase eta 
J.Biol.Chem., 289, pp. 16867 - 16882, 2014.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 61

Cell Constants:

a = 98.312   b = 98.312   c = 81.596 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1742 for 47707 reflections in the resolution range 42.57 to 1.717 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)