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NDB ID: 5C0W    PDB ID: 5C0W 


Title:

STRUCTURE OF A 12-SUBUNIT NUCLEAR EXOSOME COMPLEX BOUND TO SINGLE-STRANDED RNA SUBSTRATES

Molecular Description:

Exosome complex component RRP45
Exosome complex component SKI6
Exosome complex component RRP43
Rrp46p
Exosome complex component RRP42
Exosome complex component MTR3
Exosome complex component RRP40
Exosome complex component RRP4
Exosome complex component CSL4
Exosome complex exonuclease DIS3
Exosome complex exonuclease RRP6
Exosome complex protein LRP1/RNA Complex

Deposited:

2015-06-12

Released:

2015-07-29

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 12 protein sequences

Primary Citation:

Makino, D.L., Schuch, B., Stegmann, E., Baumgartner, M., Basquin, C., Conti, E.
RNA degradation paths in a 12-subunit nuclear exosome complex. 
Nature, 524, pp. 54 - 58, 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32 2 1

Cell Constants:

a = 195.38   b = 195.38   c = 463.65 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2773 for 40199 reflections in the resolution range 59.09 to 4.6 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)