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NDB ID: 5CC1    PDB ID: 5CC1 


Title:

S425G GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - (+)GRE COMPLEX

Molecular Description:

Deposited:

2015-07-01

Released:

2015-12-23

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Hudson, W.H., Kossmann, B.R., de Vera, I.M., Chuo, S.W., Weikum, E.R., Eick, G.N., Thornton, J.W., Ivanov, I.N., Kojetin, D.J., Ortlund, E.A.
Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space. 
Proc.Natl.Acad.Sci.USA, 113, pp. 326 - 331, 2016.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 176.721   b = 39.122   c = 132.099 (Ångstroms)

α = 90.0   β = 101.1   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2464 for 36667 reflections in the resolution range 32.407 to 2.302 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)