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NDB ID: 5CP6    PDB ID: 5CP6 


Title:

NUCLEOSOME CORE PARTICLE WITH ADDUCTS FROM THE ANTICANCER COMPOUND, [(ETA6-5,8,9,10-TETRAHYDROANTHRACENE)RU(ETHYLENEDIAMINE)CL][PF6]

Molecular Description:

Histone H3.2
Histone H4
Histone H2A type 1
Histone H2B 1.1/DNA Complex

Deposited:

2015-07-21

Released:

2016-06-01

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Ma, Z., Palermo, G., Adhireksan, Z., Murray, B.S., von Erlach, T., Dyson, P.J., Rothlisberger, U., Davey, C.A.
An Organometallic Compound which Exhibits a DNA Topology-Dependent One-Stranded Intercalation Mode. 
Angew.Chem.Int.Ed.Engl., 55, pp. 7441 - 7444, 2016.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 106.57   b = 109.57   c = 182.61 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.21102 for 56191 reflections in the resolution range 76.39 to 2.6 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)