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NDB ID: 5D8T    PDB ID: 5D8T 


Title:

RNA OCTAMER CONTAINING (S)-5' METHYL, 2'-F U.

Molecular Description:

RNA oligonucleotide containing (S)-C5'-Me-2'-FU

Deposited:

2015-08-17

Released:

2016-06-29

Structural Keywords:

A DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Kel In, A.V., Zlatev, I., Harp, J., Jayaraman, M., Bisbe, A., O Shea, J., Taneja, N., Manoharan, R.M., Khan, S., Charisse, K., Maier, M.A., Egli, M., Rajeev, K.G., Manoharan, M.
Structural Basis of Duplex Thermodynamic Stability and Enhanced Nuclease Resistance of 5'-C-Methyl Pyrimidine-Modified Oligonucleotides. 
J.Org.Chem., 81, pp. 2261 - 2279, 2016.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 21 2

Cell Constants:

a = 31.172   b = 31.172   c = 84.325 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.121 for 12988 reflections in the resolution range 29.24 to 1.2 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)