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NDB ID: 5DE8    PDB ID: 5DE8 


Title:

CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN HUMAN FMRP RGG MOTIF AND G-QUADRUPLEX RNA, IRIDIUM HEXAMMINE BOUND FORM.

Molecular Description:

Fragile X mental retardation protein 1/RNA Complex

Deposited:

2015-08-25

Released:

2015-09-23

Structural Keywords:

QUADRUPLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Vasilyev, N., Polonskaia, A., Darnell, J.C., Darnell, R.B., Patel, D.J., Serganov, A.
Crystal structure reveals specific recognition of a G-quadruplex RNA by a beta-turn in the RGG motif of FMRP. 
Proc.Natl.Acad.Sci.USA, 112, pp. E5391 - E5400, 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 2

Cell Constants:

a = 57.65   b = 130.6   c = 36.7 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2019 for 5334 reflections in the resolution range 19.355 to 3.1003 Ångstroms with Fobs >  1.36 sigma(Fobs) and with I >  0.0 sigma(I)