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NDB ID: 5DFJ    PDB ID: 5DFJ 


Title:

HUMAN APE1 E96Q/D210N MISMATCH SUBSTRATE COMPLEX

Molecular Description:

DNA-(apurinic or apyrimidinic site) lyase/DNA Complex

Deposited:

2015-08-26

Released:

2015-10-14

Structural Keywords:

B DOUBLE HELIX, BULGE

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Freudenthal, B.D., Beard, W.A., Cuneo, M.J., Dyrkheeva, N.S., Wilson, S.H.
Capturing snapshots of APE1 processing DNA damage. 
Nat.Struct.Mol.Biol., 22, pp. 924 - 931, 2015.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1

Cell Constants:

a = 44.462   b = 60.668   c = 73.161 (Ångstroms)

α = 82.78   β = 80.28   γ = 89.2 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1606 for 63349 reflections in the resolution range 23.454 to 1.85 Ångstroms with Fobs >  1.96 sigma(Fobs) and with I >  0.0 sigma(I)