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NDB ID: 5DNM    PDB ID: 5DNM 


Title:

NUCLEOSOME CORE PARTICLE CONTAINING ADDUCTS OF RUTHENIUM(II)-TOLUENE PTA COMPLEX

Molecular Description:

Histone H3.2
Histone H4
Histone H2A
Histone H2B 1.1/DNA Complex

Deposited:

2015-09-10

Released:

2016-09-14

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Adhireksan, Z., Palermo, G., Riedel, T., Ma, Z., Muhammad, R., Rothlisberger, U., Dyson, P.J., Davey, C.A.
Allosteric cross-talk in chromatin can mediate drug-drug synergy 
Nat Commun, 8, pp. 14860 - 14860, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 106.68   b = 109.82   c = 182.34 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.20892 for 49694 reflections in the resolution range 58.612 to 2.81 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)