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NDB ID: 5EGO    PDB ID: 5EGO 


Title:

HOXB13-MEIS1 HETERODIMER BOUND TO METHYLATED DNA

Molecular Description:

Homeobox protein Meis1
Homeobox protein Hox-B13/DNA Complex

Deposited:

2015-10-27

Released:

2016-11-09

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Yin, Y., Morgunova, E., Jolma, A., Kaasinen, E., Sahu, B., Khund-Sayeed, S., Das, P.K., Kivioja, T., Dave, K., Zhong, F., Nitta, K.R., Taipale, M., Popov, A., Ginno, P.A., Domcke, S., Yan, J., Schubeler, D., Vinson, C., Taipale, J.
Impact of cytosine methylation on DNA binding specificities of human transcription factors. 
Science, 356, pp. - , 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 40.976   b = 51.48   c = 113.575 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2296 for 8214 reflections in the resolution range 38.544 to 2.54 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)