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NDB ID: 5FRM    PDB ID: 5FRM 


Title:

CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS (PFV) INTASOME IN COMPLEX WITH MAGNESIUM AND THE INSTI XZ384 (COMPOUND 4A)

Molecular Description:

PFV INTEGRASE

Deposited:

2015-12-18

Released:

2016-02-17

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Zhao, X.Z., Smith, S.J., Maskell, D.P., Metifiot, M., Pye, V.E., Fesen, K., Marchand, C., Pommier, Y., Cherepanov, P., Hughes, S.H., Burke, T.R.J.
HIV-1 Integrase Strand Transfer Inhibitors with Reduced Susceptibility to Drug Resistant Mutant Integrases. 
Acs Chem.Biol., 11, pp. 1074 - , 2016.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 21 2

Cell Constants:

a = 159.737   b = 159.737   c = 123.528 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1858 for 50703 reflections in the resolution range 48.897 to 2.58 Ångstroms with Fobs >  0.17 sigma(Fobs) and with I >  0.0 sigma(I)