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NDB ID: 5GWJ    PDB ID: 5GWJ 


Title:

STRUCTURE OF A HUMAN TOPOISOMERASE IIBETA FRAGMENT IN COMPLEX WITH DNA AND E7873S

Molecular Description:

DNA topoisomerase 2-beta/DNA Complex

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Wang, Y.R., Chen, S.F., Wu, C.C., Liao, Y.W., Lin, T.S., Liu, K.T., Chen, Y.S., Li, T.K., Chien, T.C., Chan, N.L.
Producing irreversible topoisomerase II-mediated DNA breaks by site-specific Pt(II)-methionine coordination chemistry 
Nucleic Acids Res., 45, pp. 10861 - 10871, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 80.178   b = 176.99   c = 94.414 (Ångstroms)

α = 90.0   β = 111.5   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1843 for 77663 reflections in the resolution range 29.677 to 2.566 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)