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NDB ID: 5HL7    PDB ID: 5HL7 


Title:

THE CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT OF STAPHYLOCOCCUS AUREUS IN COMPLEX WITH LEFAMULIN

Molecular Description:

50S ribosomal protein L2
50S ribosomal protein L3
50S ribosomal protein L4
50S ribosomal protein L5
50S ribosomal protein L6
50S ribosomal protein L13
50S ribosomal protein L14
50S ribosomal protein L15
50S ribosomal protein L16
50S ribosomal protein L17
50S ribosomal protein L18
50S ribosomal protein L19
50S ribosomal protein L20
50S ribosomal protein L21
50S ribosomal protein L22
50S ribosomal protein L23
50S ribosomal protein L24
50S ribosomal protein L25
50S ribosomal protein L27
50S ribosomal protein L28
50S ribosomal protein L29
50S ribosomal protein L30
50S ribosomal protein L32
50S ribosomal protein L34
50S ribosomal protein L35
50S ribosomal protein L36/RNA Complex

Structural Keywords:

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 26 protein sequences

Primary Citation:

Eyal, Z., Matzov, D., Krupkin, M., Paukner, S., Riedl, R., Rozenberg, H., Zimmerman, E., Bashan, A., Yonath, A.
A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism. 
Sci Rep, 6, pp. 39004 - 39004, 2016.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 65 2 2

Cell Constants:

a = 282.112   b = 282.112   c = 875.343 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1888 for 235811 reflections in the resolution range 49.93 to 3.55 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)