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NDB ID: 5I42    PDB ID: 5I42 


Title:

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH A DNA APTAMER, AZTTP, AND CA(2+) ION

Molecular Description:

HIV-1 reverse transcriptase p66 subunit
HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT/DNA Complex

Deposited:

2016-02-11

Released:

2016-06-01

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Das, K., Balzarini, J., Miller, M.T., Maguire, A.R., DeStefano, J.J., Arnold, E.
Conformational States of HIV-1 Reverse Transcriptase for Nucleotide Incorporation vs Pyrophosphorolysis-Binding of Foscarnet. 
Acs Chem.Biol., 11, pp. 2158 - 2164, 2016.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 90.151   b = 132.192   c = 139.658 (Ångstroms)

α = 90.0   β = 97.15   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2217 for 46295 reflections in the resolution range 48.449 to 3.3 Ångstroms with Fobs >  1.4 sigma(Fobs) and with I >  0.0 sigma(I)