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NDB ID: 5IIJ    PDB ID: 5IIJ 


Title:

CRYSTAL STRUCTURE OF THE PRE-CATALYTIC TERNARY COMPLEX OF DNA POLYMERASE LAMBDA WITH A TEMPLATING 8-OXO-DG AND AN INCOMING DCTP

Molecular Description:

DNA polymerase lambda/DNA Complex

Deposited:

2016-03-01

Released:

2016-08-17

Structural Keywords:

B DOUBLE HELIX, NICKED

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Burak, M.J., Guja, K.E., Hambardjieva, E., Derkunt, B., Garcia-Diaz, M.
A fidelity mechanism in DNA polymerase lambda promotes error-free bypass of 8-oxo-dG. 
Embo J., 35, pp. 2045 - 2059, 2016.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 55.749   b = 62.85   c = 140.076 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1982 for 52694 reflections in the resolution range 41.706 to 1.724 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)