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NDB ID: 5J2P    PDB ID: 5J2P 


Title:

HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH DNA THAT HAS INCORPORATED EFDA-MP AT THE P-(POST-TRANSLOCATION) SITE AND A SECOND EFDA-MP AT THE N-(PRE-TRANSLOCATION) SITE

Molecular Description:

Gag-Pol polyprotein/DNA Complex

Deposited:

2016-03-29

Released:

2016-08-03

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Salie, Z.L., Kirby, K.A., Michailidis, E., Marchand, B., Singh, K., Rohan, L.C., Kodama, E.N., Mitsuya, H., Parniak, M.A., Sarafianos, S.G.
Structural basis of HIV inhibition by translocation-defective RT inhibitor 4'-ethynyl-2-fluoro-2'-deoxyadenosine (EFdA). 
Proc.Natl.Acad.Sci.USA, 113, pp. 9274 - 9279, 2016.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 165.977   b = 170.183   c = 99.695 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1959 for 46856 reflections in the resolution range 63.78 to 2.53 Ångstroms with Fobs >  1.33 sigma(Fobs) and with I >  0.0 sigma(I)