A Portal for Three-dimensional Structural Information about Nucleic Acids
As of 1-Apr-2020 number of released structures: 10687
Search for released structures

NDB ID: 5JS2    PDB ID: 5JS2 


Title:

HUMAN ARGONAUTE-2 BOUND TO A MODIFIED SIRNA

Molecular Description:

Protein argonaute-2/RNA Complex

Deposited:

2016-05-07

Released:

2016-07-20

Structural Keywords:

SMALL NA FRAGMENT

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Schirle, N.T., Kinberger, G.A., Murray, H.F., Lima, W.F., Prakash, T.P., MacRae, I.J.
Structural Analysis of Human Argonaute-2 Bound to a Modified siRNA Guide. 
J.Am.Chem.Soc., 138, pp. 8694 - 8697, 2016.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 63.102   b = 107.552   c = 68.893 (Ångstroms)

α = 90.0   β = 107.39   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2243 for 18151 reflections in the resolution range 38.983 to 2.954 Ångstroms with Fobs >  1.36 sigma(Fobs) and with I >  0.0 sigma(I)