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NDB ID: 5L1L    PDB ID: 5L1L 


Title:

POSTINSERTION COMPLEX OF HUMAN DNA POLYMERASE ETA BYPASSING AN O6-METHYL-2'-DEOXYGUANOSINE : DT SITE

Molecular Description:

DNA polymerase eta/DNA Complex

Deposited:

2016-07-29

Released:

2016-10-05

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Patra, A., Zhang, Q., Guengerich, F.P., Egli, M.
Mechanisms of Insertion of dCTP and dTTP Opposite the DNA Lesion O6-Methyl-2'-deoxyguanosine by Human DNA Polymerase eta. 
J.Biol.Chem., 291, pp. 24304 - 24313, 2016.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 61

Cell Constants:

a = 98.355   b = 98.355   c = 82.034 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.15855 for 54491 reflections in the resolution range 50.0 to 1.62 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)