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NDB ID: 5L1Z    PDB ID: 5L1Z 


Title:

TAR COMPLEX WITH HIV-1 TAT-AFF4-P-TEFB

Molecular Description:

Cyclin-dependent kinase 9
Cyclin-T1
AF4/FMR2 family member 4
Protein Tat/RNA Complex

Deposited:

2016-07-29

Released:

2016-10-26

Structural Keywords:

DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Schulze-Gahmen, U., Echeverria, I., Stjepanovic, G., Bai, Y., Lu, H., Schneidman-Duhovny, D., Doudna, J.A., Zhou, Q., Sali, A., Hurley, J.H.
Insights into HIV-1 proviral transcription from integrative structure and dynamics of the Tat:AFF4:P-TEFb:TAR complex. 
Elife, 5, pp. - , 2016.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 32 2 1

Cell Constants:

a = 146.87   b = 146.87   c = 103.75 (Ångstroms)

α = 90.0   β = 90.0   γ = 120.0 (degrees)

Refinement:

The structure was refined using the CNS program. The R value is 0.0 for 3595 reflections in the resolution range 500.0 to 5.9 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)