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NDB ID: 5LIT    PDB ID: 5LIT 


Title:

FUNCTIONAL AND STRUCTURAL ANALYSIS OF AT-SPECIFIC MINOR GROOVE BINDERS THAT DISRUPT DNA-PROTEIN INTERACTIONS AND CAUSE DISINTEGRATION OF THE TRYPANOSOMA BRUCEI KINETOPLAST

Molecular Description:

DNA (5'-D(*AP*AP*AP*TP*TP*T)-3')

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Acosta-Reyes, F., Campos, J.L., Dardonville, C., Ebiloma, G., Lagartera, L., Lemgruber, L., Millan, C.R., Nue Martinez, J.J., Saperas, N., de Koning, H.P.
Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast 
Nucleic Acids Res., , pp. - , 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 1 2 1

Cell Constants:

a = 22.33   b = 40.25   c = 72.423 (Ångstroms)

α = 90.0   β = 93.67   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC 5.8.0135 program. The R value is 0.12284 for 15741 reflections in the resolution range 36.14 to 1.25 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)