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NDB ID: 5LTY    PDB ID: 5LTY 


Title:

HOMEOBOX TRANSCRIPTION FACTOR CDX2 BOUND TO METHYLATED DNA

Molecular Description:

Homeobox protein CDX-2/DNA Complex

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Yin, Y., Morgunova, E., Jolma, A., Kaasinen, E., Sahu, B., Khund-Sayeed, S., Das, P.K., Kivioja, T., Dave, K., Zhong, F., Nitta, K.R., Taipale, M., Popov, A., Ginno, P.A., Domcke, S., Yan, J., Schubeler, D., Vinson, C., Taipale, J.
Impact of cytosine methylation on DNA binding specificities of human transcription factors. 
Science, 356, pp. - , 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

I 1 2 1

Cell Constants:

a = 68.882   b = 46.613   c = 120.428 (Ångstroms)

α = 90.0   β = 98.46   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.2039 for 10459 reflections in the resolution range 63.29 to 2.66 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)