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NDB ID: 5M3H    PDB ID: 5M3H 


Title:

BAT INFLUENZA A/H17N10 POLYMERASE BOUND TO FOUR HEPTAD REPEATS OF SERINE 5 PHOSPHORYLATED POL II CTD

Molecular Description:

Polymerase acidic protein
RNA-directed RNA polymerase catalytic subunit
Polymerase basic protein 2
TYR-SER-PRO-THR-SEP-PRO/RNA Complex

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 4 protein sequences

Primary Citation:

Lukarska, M., Fournier, G., Pflug, A., Resa-Infante, P., Reich, S., Naffakh, N., Cusack, S.
Structural basis of an essential interaction between influenza polymerase and Pol II CTD. 
Nature, 541, pp. 117 - 121, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 1 2 1

Cell Constants:

a = 269.49   b = 147.52   c = 88.48 (Ångstroms)

α = 90.0   β = 97.22   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX (1.10_2155: ???) program. The R value is 0.2118 for 117997 reflections in the resolution range 49.528 to 2.5 Ångstroms with Fobs >  1.36 sigma(Fobs) and with I >  0.0 sigma(I)