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NDB ID: 5NO1    PDB ID: 5NO1 


Title:

CRYSTAL STRUCTURE OF THE PROTOTYPE FOAMY VIRUS (PFV) INTASOME IN COMPLEX WITH MAGNESIUM AND THE INSTI XZ407 (COMPOUND 5G)

Molecular Description:

Integrase/DNA Complex

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Zhao, X.Z., Smith, S.J., Maskell, D.P., Metifiot, M., Pye, V.E., Fesen, K., Marchand, C., Pommier, Y., Cherepanov, P., Hughes, S.H., Burke, T.R.
Structure-Guided Optimization of HIV Integrase Strand Transfer Inhibitors. 
J. Med. Chem., 60, pp. 7315 - 7332, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 41 21 2

Cell Constants:

a = 158.57   b = 158.57   c = 123.06 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1779 for 48668 reflections in the resolution range 56.063 to 2.6 Ångstroms with Fobs >  1.37 sigma(Fobs) and with I >  0.0 sigma(I)