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NDB ID: 5OT2    PDB ID: 5OT2 

Title:

RNA POLYMERASE II ELONGATION COMPLEX IN THE PRESENCE OF 3D-NAPHT-A

Molecular Description:

DNA-directed RNA polymerase II subunit RPB1
DNA-directed RNA polymerase II subunit RPB2
DNA-directed RNA polymerase II subunit RPB3
DNA-directed RNA polymerase II subunit RPB4
DNA-directed RNA polymerases I
II
and III subunit RPABC1
DNA-directed RNA polymerases I
II
and III subunit RPABC2
DNA-directed RNA polymerase II subunit RPB7
DNA-directed RNA polymerases I
II
and III subunit RPABC3
DNA-directed RNA polymerase II subunit RPB9
DNA-directed RNA polymerases I
II
and III subunit RPABC5
DNA-directed RNA polymerase II subunit RPB11
DNA-directed RNA polymerases I
II
and III subunit RPABC4/DNA Complex

Structural Keywords:

RH DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 12 protein sequences

Primary Citation:

Malvezzi, S., Farnung, L., Aloisi, C.M.N., Angelov, T., Cramer, P., Sturla, S.J.
Mechanism of RNA polymerase II stalling by DNA alkylation. 
Proc. Natl. Acad. Sci. U.S.A., 114, pp. 12172 - 12177, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

C 2 2 21

Cell Constants:

a = 221.35   b = 394.93   c = 283.71 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1789 for 202994 reflections in the resolution range 49.882 to 3.2 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)

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