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NDB ID: 5T7X    PDB ID: 5T7X 


Title:

CRYSTAL STRUCTURE OF HHV-4 EBNA1 DNA BINDING DOMAIN (PATIENT-DERIVED, NASOPHARYNGEAL CARCINOMA) BOUND TO DNA

Molecular Description:

Epstein-Barr nuclear antigen 1/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Dheekollu, J., Malecka, K., Wiedmer, A., Delecluse, H.J., Chiang, A.K., Altieri, D.C., Messick, T.E., Lieberman, P.M.
Carcinoma-risk variant of EBNA1 deregulates Epstein-Barr Virus episomal latency. 
Oncotarget, 8, pp. 7248 - 7264, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 60.025   b = 64.904   c = 111.783 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1902 for 21843 reflections in the resolution range 23.373 to 2.35 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)