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NDB ID: 5TXM    PDB ID: 5TXM 


Title:

STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DDATP

Molecular Description:

HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT
HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT/DNA Complex

Structural Keywords:

B DOUBLE HELIX, OPEN HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Das, K., Martinez, S.E., Arnold, E.
Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance. 
Antimicrob. Agents Chemother., 61, pp. - , 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 90.337   b = 133.946   c = 139.399 (Ångstroms)

α = 90.0   β = 97.71   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1848 for 87934 reflections in the resolution range 46.046 to 2.7 Ångstroms with Fobs >  1.38 sigma(Fobs) and with I >  0.0 sigma(I)