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NDB ID: 5TXO    PDB ID: 5TXO 


Title:

STRUCTURE OF Q151M COMPLEX (A62V, V75I, F77L, F116Y, Q151M) MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) TERNARY COMPLEX WITH A DOUBLE STRANDED DNA AND AN INCOMING DATP

Molecular Description:

HIV-1 REVERSE TRANSCRIPTASE P66 SUBUNIT
HIV-1 REVERSE TRANSCRIPTASE P51 SUBUNIT/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 2 protein sequences

Primary Citation:

Das, K., Martinez, S.M., Arnold, E.
Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex that Confer Multi-Nucleoside Drug Resistance 
Antimicrob.Agents Chemother., , pp. - , 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 89.99   b = 132.93   c = 139.12 (Ångstroms)

α = 90.0   β = 97.38   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX (1.10_2155: ???) program. The R value is 0.192 for 104909 reflections in the resolution range 45.989 to 2.546 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)