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NDB ID: 5U2R    PDB ID: 5U2R 


Title:

PRECATALYTIC TERNARY COMPLEX OF HUMAN DNA POLYMERASE BETA WITH GAPPED DNA SUBSTARTE, INCOMING L-DCTP AND CA2+

Molecular Description:

DNA polymerase beta/DNA Complex

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Vyas, R., Reed, A.J., Raper, A.T., Zahurancik, W.J., Wallenmeyer, P.C., Suo, Z.
Structural basis for the D-stereoselectivity of human DNA polymerase beta. 
Nucleic Acids Res., 45, pp. 6228 - 6237, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 1 21 1

Cell Constants:

a = 50.91   b = 80.16   c = 55.64 (Ångstroms)

α = 90.0   β = 107.68   γ = 90.0 (degrees)

Refinement:

The structure was refined using the REFMAC program. The R value is 0.192 for 37460 reflections in the resolution range 26.96 to 1.8 Ångstroms with Fobs >  0.0 sigma(Fobs) and with I >  0.0 sigma(I)