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NDB ID: 5UDL    PDB ID: 5UDL 


Title:

IFIT1 N216A MONOMERIC MUTANT (L457E/L464E) WITH M7GPPP-AAAA (ANTI CONFORMATION OF CAP)

Molecular Description:

Interferon-induced protein with tetratricopeptide repeats 1/RNA Complex

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Abbas, Y.M., Laudenbach, B.T., Martinez-Montero, S., Cencic, R., Habjan, M., Pichlmair, A., Damha, M.J., Pelletier, J., Nagar, B.
Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2'-O methylations. 
Proc. Natl. Acad. Sci. U.S.A., 114, pp. E2106 - E2115, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 42 2 2

Cell Constants:

a = 111.76   b = 111.76   c = 92.992 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.1652 for 71790 reflections in the resolution range 40.074 to 1.65 Ångstroms with Fobs >  1.35 sigma(Fobs) and with I >  0.0 sigma(I)