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NDB ID: 5UHC    PDB ID: 5UHC     NAKB(beta): 5UHC 

Title:

CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TRANSCRIPTION INITIATION COMPLEX CONTAINING 3NT RNA IN COMPLEX WITH RIFAMPIN

Molecular Description:

DNA-directed RNA polymerase subunit alpha
DNA-directed RNA polymerase subunit beta
DNA-directed RNA polymerase subunit beta'
DNA-directed RNA polymerase subunit omega
RNA polymerase sigma factor SigA/DNA Complex

Deposited:

2017-01-11

Released:

2017-04-12

Structural Keywords:

B DOUBLE HELIX, OPEN HELIX

Nucleic Acid Sequence:

Click to show/hide 3 nucleic acid sequences

Protein Sequence:

Click to show/hide 5 protein sequences

Primary Citation:

Lin, W., Mandal, S., Degen, D., Liu, Y., Ebright, Y.W., Li, S., Feng, Y., Zhang, Y., Mandal, S., Jiang, Y., Liu, S., Gigliotti, M., Talaue, M., Connell, N., Das, K., Arnold, E., Ebright, R.H.
Structural Basis of Mycobacterium tuberculosis Transcription and Transcription Inhibition. 
Mol. Cell, 66, pp. 169 - 179.e8, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 21 21 21

Cell Constants:

a = 150.05   b = 167.39   c = 195.228 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX program. The R value is 0.2072 for 43856 reflections in the resolution range 48.807 to 3.796 Ångstroms with Fobs >  1.49 sigma(Fobs) and with I >  0.0 sigma(I)

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