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NDB ID: 5UZ1    PDB ID: 5UZ1 


Title:

SOLUTION STRUCTURE OF A DNA DODECAMER WITH 5-METHYLCYTOSINE AT THE 3RD POSITION AND 8-OXOGUANINE AT THE 10TH POSITION

Molecular Description:

DNA (5'-D(*CP*GP*(DMC)P*GP*AP*AP*TP*TP*CP*(8OG)P*CP*G)-3')

Deposited:

2017-02-24

Released:

2017-05-31

Structural Keywords:

B DOUBLE HELIX

Nucleic Acid Sequence:

Click to show/hide 1 nucleic acid sequences

Protein Sequence:

No Protein Sequence Found

Primary Citation:

Gruber, D.R., Toner, J.J., Miears, H.L., Shernyukov, A.V., Kiryutin, A.S., Lomzov, A.A., Endutkin, A.V., Grin, I.R., Petrova, D.V., Kupryushkin, M.S., Yurkovskaya, A.V., Johnson, E.C., Okon, M., Bagryanskaya, E.G., Zharkov, D.O., Smirnov, S.L.
Oxidative damage to epigenetically methylated sites affects DNA stability, dynamics and enzymatic demethylation. 
Nucleic Acids Res., 46, pp. 10827 - 10839, 2018.

Experimental Information:

SOLUTION NMR

Number of Models:

Number of Models: 12 Structures

Sample Details:

50 mM sodium chloride, 10 mM potassium chloride, 0.1 mM EDTA, 1 mM DNA (5'-D(*CP*GP*(DMC)P*GP*AP*AP*TP*TP*CP*(8OG)P*CP*G)-3'), 100% D2O 100% D2O