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NDB ID: 5V0B    PDB ID: 5V0B 


Title:

CRYSTAL STRUCTURE OF HUMAN EXONUCLEASE 1 EXO1 (WT) IN COMPLEX WITH 5' RECESSED-END DNA (RIX)

Molecular Description:

Exonuclease 1/DNA Complex

Structural Keywords:

B DOUBLE HELIX, OVERHANGING BASES

Nucleic Acid Sequence:

Click to show/hide 2 nucleic acid sequences

Protein Sequence:

Click to show/hide 1 protein sequences

Primary Citation:

Shi, Y., Hellinga, H.W., Beese, L.S.
Interplay of catalysis, fidelity, threading, and processivity in the exo- and endonucleolytic reactions of human exonuclease I. 
Proc. Natl. Acad. Sci. U.S.A., 114, pp. 6010 - 6015, 2017.

Experimental Information:

X-RAY DIFFRACTION

Space Group:

P 43 21 2

Cell Constants:

a = 73.764   b = 73.764   c = 182.796 (Ångstroms)

α = 90.0   β = 90.0   γ = 90.0 (degrees)

Refinement:

The structure was refined using the PHENIX DEV_1839 program. The R value is 0.211 for 15256 reflections in the resolution range 38.85 to 2.63 Ångstroms with Fobs >  1.34 sigma(Fobs) and with I >  0.0 sigma(I)